Melatonin for Anxiety: Calming Effects and Anxiety Management

Melatonin is produced in the pineal gland and the gastrointestinal tract, making it 400 times the amount of melatonin in the pineal gland. Melatonin for anxiety sleep and its antioxidant properties is typically consumed between 0.3mg (300 mcg) to 10mg.

However, starting with a lower dosage is critical in eliminating other factors and nutrient deficiencies contributing to insomnia and anxiety. 

Melatonin is a hormone and an antioxidant that protects cellular health and the cell’s mitochondria. 

Melatonin is suggested to have neuroprotective properties, as it has been reported to reduce neuronal damage in various animal models of neurological conditions, including Alzheimer’s disease and Parkinson’s disease.

How long does melatonin take to work for anxiety?

This is inconclusive since melatonin indirectly affects anxiety by reducing insomnia and improving sleep quality and neuroprotective properties. However, you can see results in your overall mood and energy levels as early as one day after you begin taking it, and it takes 30 minutes to an hour to begin working. 

If you have racing thoughts before bed, taking magnesium combined with melatonin and yoga can dramatically decrease your thoughts and help you feel more at ease. 

A time-released melatonin can help you fall asleep and stay asleep if you wake up in the middle of the night.

Symptoms of Anxiety

  • Heart Racing
  • Racing thoughts
  • Excessive worry
  • Excess sweating
  • Muscle Tension
  • Knots in your stomach
  • Shallow breathing
  • Headaches
  • Jaw tightness
  • Hot flushes
  • Inability to sit still
  • Excessive fidgeting or leg bouncing 
  • Insomnia
  • Easily exhausted 
  • Irritability

Calming Benefits of Melatonin

Melatonin penetrates the placenta during pregnancy and is secreted into a mother’s milk in high amounts at night and undetectable amounts during the day. Melatonin in breast milk follows a circadian rhythm. 

A circadian rhythm regulates cells and creates the sleep-wake cycle. Adjusting your lifestyle around your circadian rhythm could improve your sleep quality, melatonin supplementation, and your body’s natural production of melatonin. 

If taking melatonin for anxiety is not enough, combining it with other natural sleep aids and supplements can increase the overall effectiveness of supporting a calm mind and body. 

Melatonin causes your body to feel more relaxed and your eyes to feel heavier before bedtime, but it is not recommended to be taken during the day. 

Magnesium, 5-HTP, or Gaia’s CALM ASAP are fantastic options if you are looking for daytime calming effects. 

Cognitive-behavioral therapy, natural benzodiazepines or antidepressants, or other behavioral interventions may be more beneficial.

Melatonin for Anxiety Dosage

Melatonin receptor disorders can cause a disruption in glucose metabolism, which increases the risk of diabetes. Elevated blood sugar can contribute to anxiety.

Taking 1mg of melatonin per night with 200-400mg of magnesium can help increase sleep, regulate circadian rhythms, and decrease magnesium deficiencies.

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While melatonin primarily aids in improving sleep quality and regulating circadian rhythms, it may indirectly help with anxiety symptoms exacerbated by sleep problems.

By taking melatonin, individuals with anxiety-related sleep problems may find it easier to fall asleep faster and stay asleep throughout the night. This improved sleep can reduce anxiety symptoms, as restful sleep is essential for maintaining proper cognitive and emotional functioning.

An imbalance of serotonin and epinephrine neurotransmitters can be a concern for someone with Generalized Anxiety Disorder. 

Enzymes in the pineal gland help convert serotonin into melatonin. Therefore, lower serotonin levels in individuals with ADHD, anxiety, and depression may be more susceptible to low melatonin production and sleep issues. 

Is melatonin effective for anxiety?

Starting with 1mg of melatonin or less is recommended to avoid grogginess in the morning, and ensure you take it 1 hour before your desired bedtime. Taking melatonin for anxiety and sleep in combination with guided meditation can increase your sleep duration, help you fall asleep faster, and improve your sleep quality. 

It is essential to address the root causes of anxiety and sleep problems through proper sleep hygiene, relaxation techniques, and, if necessary, seeking professional help.

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However, recent research has suggested that it may also impact anxiety symptoms. While melatonin is not a primary treatment for anxiety disorders, some studies have shown promising results in reducing anxiety levels.

The effectiveness of melatonin for anxiety varies among individuals, and more research is needed to understand its full potential. It is important to note that melatonin is not a substitute for professional medical advice or prescribed treatments for anxiety.

If you are looking for vitamin supplements for stress as well as additional mental health support, check out our Holistic Anxiety Relief Course or our Coaching Program.

Melatonin’s Immune Benefits

Melatonin is shown to have immunomodulatory properties and cytoprotective effects. It can both enhance and inhibit immune responses depending on the systemic condition. Melatonin also has antioxidant properties and can protect against oxidative damage.

Potential Side Effects:

Melatonin is generally considered safe for short-term use but may cause side effects in some individuals. These can include drowsiness, headache, dizziness, and nausea. It is recommended to start with a low dose and consult a healthcare professional before using melatonin for anxiety.

If you are considering using melatonin for anxiety, it is crucial to consult with a healthcare professional to discuss your specific situation and determine the appropriate course of action. They can guide dosage potential interactions with other medications and help monitor your progress.

Sleep’s Effect on Anxiety

Poor sleep quality is associated with anxiety and depression. Taking melatonin for anxiety improves insomnia. Magnesium Bisglycinate can increase natural melatonin production and improve sleep quality and duration. 

Insomnia can lead to risky behaviors such as car accidents, self-medication, decreased job performance, and damage to close relationships. Anxiety and depression can decrease the quality of an individual’s sleep, and poor sleep can contribute to anxiety and depression. Insomnia can also contribute to daytime sleepiness, causing more anxiety symptoms.

Among the participants with insomnia, the following comorbidity patterns were observed:

  • 52.4% had neither anxiety nor depression.
  • 21.7% had anxiety only.
  • 7.2% had depression only.
  • 18.6% had both anxiety and depression.

This suggests a negative impact on daytime alertness, general sleep quality, and insomnia severity when both anxiety and depression were present. This suggests that sleep quality plays a role in the relationship between psychiatric problems and insomnia severity.

Melatonin for Sleep

Melatonin is a hormone that helps regulate the sleep-wake cycle. It can be used as a supplement to improve sleep quality, especially for individuals with insomnia. Melatonin works by signaling to the body that it is time to sleep, helping to promote a sense of relaxation and drowsiness. It is typically taken orally in tablets or capsules, and the recommended dosage can vary depending on the individual’s needs. It is essential to consult with a healthcare professional before starting melatonin supplementation to ensure proper usage and address potential interactions or side effects.

Depression

Neuroinflammation interferes with emotional regulation and can contribute to disorders such as Generalized Anxiety Disorder (GAD) and Major Depressive Disorder (MDD). Depression interferes with circadian rhythm, which makes using melatonin for depression highly beneficial. 

Melatonin is shown to increase neuroplasticity, which means the nervous system can change its response to intrinsic or extrinsic stimuli by changing the structure and connections. 

Stress, poor diet, medications, poor gut health, and aging can all increase the risk of neuroinflammation due to changes in the immune system. The neurotoxic effects of neuroinflammation contribute to emotional dysregulation, contributing to depression. 

Since individuals with depression frequently sleep at times that do not align with their circadian rhythms, melatonin helps increase fatigue if taken an hour before the desired bedtime (11 p.m. or earlier). 

By taking melatonin for depression, individuals are syncing their sleep with their body’s rhythms. Furthermore, brain scans of individuals with depression have decreased sleep continuity and NREM and REM sleep, which are critical for processing trauma and stress. 

The suprachiasmatic nucleus (SCN) in the hypothalamus, which regulates circadian rhythms, is discussed as a central pacemaker. Melatonin, synthesized in response to SCN signals, is crucial in moderating circadian rhythms, especially sleep regulation.

Melatonin might influence mood through various physiological actions beyond circadian rhythm regulation.

Mindfulness

Mindfulness is a concept that involves being in the present moment without judgment and it can additionally focus on your breathing and your surroundings. Mindfulness is highly beneficial for both anxiety and depression and can complement the benefits of melatonin for anxiety very well. 

Conclusion

It is crucial to seek guidance from a healthcare professional and explore comprehensive approaches to managing anxiety, incorporating proper sleep habits, relaxation techniques, and, if necessary, other therapeutic interventions.


Melatonin is a hormone naturally produced by the body that regulates sleep-wake cycles. It has gained attention for its potential role in managing anxiety symptoms. This report explores the use of melatonin for anxiety, its effectiveness, potential side effects, and considerations.

In conclusion, while melatonin shows promise in managing anxiety symptoms, it is important to approach its use cautiously. It is not a standalone treatment for anxiety disorders, and professional medical advice should be sought before incorporating melatonin into your anxiety management plan.

References
Tordjman, S., Chokron, S., Delorme, R., Charrier, A., Bellissant, E., Jaafari, N., & Fougerou, C. (2017). Melatonin: Pharmacology, Functions and Therapeutic Benefits. Current Neuropharmacology, 15(3), 434-443. https://doi.org/10.2174/1570159X14666161228122115

Originally posted 2023-09-25 04:35:05.

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Hello! My name is Megan Santiago, B.S in Psychology, I have a Master's Degree in Mental Health Counseling and I am currently seeing clients as a Mental Health Counselor Intern. I am the Owner and Founder of Holistic-Momma.com. A little bit about me, I am OBSESSED with all things holistic health. I believe we can heal our physical bodies if we first heal our minds. I am a psychology major; I've worked alongside Naturopathic Doctors, Chiropractors, and numerous practitioners. I was a health educator for a well-known supplement brand, and now I share my experience and knowledge. I hope you learn something while on my site, and feel free to contact me with any questions!

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